Antimony can also cause problems with the lungs, heart, and stomach. ANTIMONY TRIOXIDE 256 Cancer There are inadequate data to assess the carcinogenicity of antimony trioxide from dermal or oral exposures. Pentavalent antimony compounds have been used for the treatment of leishmaniasis. ATSDR can also tell you the location of occupational and environmental health clinics. The state of California lists antimony trioxide as a chemical known to cause cancer. It is brought into this country from other countries for processing. The level of exposure depends upon the dose, duration, and work being done. How can I protect myself and my family from antimony? It is used to fireproof fabrics, paper and plastics, as a paint pigment and for many other uses. Rat oral LD 50 >34 g kg −1. Ahmed Mostafa, M.D., Ryan Surmaitis, D.O., Maricel Dela Cruz, D.O., Michael Greenberg, M.D., Muhammad Khalid, M.D. These clinics specialize in They can potentially be exposed when using consumer products containing antimony trioxide or breathing contaminated air. Antimony trioxide is a mild primary eye irritant in rabbits. Antimony carcinogenicity evidence involving workers is inadequate, based on confounding, small sample sizes, incomparability across studies, and inadequate reference populations. A cancer assessment for antimony trioxide is not available on IRIS (U.S. EPA, 2008) or in the HEAST (U.S. EPA, 1997). For more information go to www.P65Warnings.ca.gov In 1989, the International Agency for Research on Cancer (IARC) concluded that Diantimony Trioxide is possibly carcinogenic to humans (Group 2B), and Antimony Trisulfide is not classifiable with regards to its carcinogenicity to humans (Group 3). The in vivo genotoxicity of antimony trioxide was studied using single and repeat dose mouse bone marrow micronucleus tests, and the rat liver unscheduled DNA synthesis assay. EPA has not classified antimony for carcinogenicity. Carcinogenic effects of antimony trioxide and antimony ore concentrate in rats. Chemical Listing Details. These archived materials frequently include presentations, background materials, and public comments. Chemical compounds based on antimony are used as pigments – one of them, antimony trioxide is also used as a flame retardant in textiles and plastics. recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. Before sharing sensitive information, make sure you're on a federal government site. What is antimony trioxide? (di)antimony trioxide 1309-64-4 >98.0 lead monoxide 1317-36-8 <0.1% (di)arsenic trioxide 1327-53-3 <0.1% Section 4 - First Aid Measures Description of necessary measures, subdivided according to the different routes of exposure: General advice: If exposed or concerned: Get medical advice/attention. This list contains substances to which pregnant workers and workers who have recently given birth or are breastfeeding may not be exposed. Arsenic trioxide is sometimes given in combination with another medicine called tretinoin. The primary hazard is the threat to the environment. Antimony trioxide was last classified by the International Agency for Research on Cancer (IARC) in 1989 as Group 2B, possibly carcinogenic to humans, based on inadequate evidence in humans and sufficient evidence in animals. Basis for Listing: AB-IARC. Inhalation (Particles) The average room-air concentration and average exposure concentration for antimony trioxide were obtained as described for the noncancer risk assessment of particles. Email: Contact CDC-INFO. An increased lung cancer risk cannot be excluded. It can be harmful to the eyes and skin. Fact Sheets; This is only a partial list; employers are obliged to prevent the exposure of these workers to any agents that may cause adverse health effect for either mother or child. Note on Accessibility: Persons with disabilities or using assistive technology may find some documents are not fully accessible. Reprotoxicity In the Russian literature women occupational exposed to antimony aerosols were reported to have a higher incidence of spontaneous abortion, premature births and menstrual disorders. Antimony trioxide is a respiratory carcinogen in female rats. Antimony is a silvery-white metal that is found in the earth's crust. Cal EPA. An expert panel, which met Jan. 24 via webcast, was unanimous in agreeing with National Toxicology Program (NTP) scientists that antimony trioxide should be classified as reasonably anticipated to be a human carcinogen in the Report on Carcinogens (RoC). The International Agency for Research on Cancer has determined that antimony trioxide is possibly carcinogenic to humans and that antimony trisulfide is not classifiable. It is insoluble in water. The US National Toxicology Program (NTP) recently recommended in its Report on Carcinogens Monograph for Antimony Trioxide that antimony trioxide be Like most polymeric oxides, Sb 2 O 3 dissolves in aqueous solutions with hydrolysis.A mixed arsenic-antimony oxide occurs in the nature as the very rare mineral stibioclaudetite. Diantimony Trioxide is listed as causing cancer (based on the IARC classification) in the California Proposition 65 or Safe Drinking Water and Toxic Enforcement Act of 1986. For assistance, email us or use our contact form and identify the documents/pages for which access is required. An official website of the United States government. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. 888-232-6348 (TTY) Reports on Peer Reviews for the Report on Carcinogens. Primarily used as a synergist for halogenated flame retardants in plastics, rubber, and textiles, all of which are used in a wide variety of consumer products. Antimony trioxide is primarily used as a flame retardant in rubber, plastics, pigments, adhesives, textiles, and paper. Evidence for lung neoplasms caused by antimony trioxide inhalation in e … Groth DH, Stettler LE, Burg JR, Busey WM, Grant GC, Wong L. This study was initiated because of a suspected increase in incidence of lung cancer in antimony smelter workers in England. Cancer; Listed as causing: Cancer. All three studies were negative. Status: Cancer hazard evaluation for potential listing in the Report on Carcinogens (RoC) Primary Uses or Exposures Oxide of trivalent (+3) antimony and … Federal government websites often end in .gov or .mil. Note: Javascript is disabled or is not supported by your browser. People are mainly exposed to antimony trioxide in the workplace. Agency for Toxic Substances and Disease Registry. It has also been listed as a possible human carcinogen by the International Agency for Research on Cancer. Antimony sesquioxide; Antimonous oxide; Antimony oxide, Oxo-oxostibanyloxystibane; Diantimony trioxide Occurence(s)/Use(s) Component of flame retardant treatment for polymers; opacifying agent for glasses, ceramics, and enamels; specialty pigments; naturally occurring as valentinite and senarmontite Antimony is toxic and several states have identified it as a safety concern for children’s products. Antimony potassium tartrate has been used worldwide as an anti-shistosomal drug. Cancer: 10/01/1990. Basis for Listing AB-IARC. *Antimony Trioxidemay be a CARCINOGEN in humans since it has been shown to cause lung cancer in animals. Ahmed Mostafa, MD, Ryan Surmaitis, DO, Maricel Dela Cruz, DO, Michael Greenberg, MD, Muhammad Khalid, MD, Division of Medical Toxicology at Drexel University College of Medicine, Caroline Braibant on behalf of the International Antimony Association, RoC Monograph- Final (correction posted April 4 2019), Process for Preparing the Draft RoC Monograph on Antimony Trioxide and Charge, Oral Comments:  Mrs. Rita Cortvrindt, Campine, Revised Draft Report on Carcinogens Monograph on Antimony Trioxide, Revised Draft Report on Carcinogens Monograph on Helicobacter pylori (Chronic Infection), BSC’s Perspective for NTP Regarding Strategic Realignment, Caroline Braibant, Geert Krekel, Nathalie Branche. Get the latest public health information from CDC and research information from NIH. Caroline Braibant - Human Health: Genotoxicity, Caroline Braibant - Human Health: Lung Toxicity and Carcinogenicity, Testing Status of Antimony Trioxide 10676-V, National Institute of Environmental Health Sciences, Federal Register notice requesting public comment on nominated substances (, Division of Medical Toxicology at Drexel University College of Medicine. What happens when I eat or breathe antimony? : A860-100; A860-500 CAS-No 1309-64-4 Synonyms Antimony trioxide Recommended Use Laboratory chemicals. Antimony(III) oxide is the inorganic compound with the formula Sb 2 O 3.It is the most important commercial compound of antimony.It is found in nature as the minerals valentinite and senarmontite. NIEHS has helpful information on accessibility. However, if you come into contact with actual antimony dust, you can experience symptoms like depression, dizziness, headaches, vomiting, kidney damage, or liver damage. RESULTS:In typical case scenarios, the occupational cancer risk from antimony trioxide was estimated to be 0.025 (25 in 1000) for persons working … Results: In typical case scenarios, the occupational cancer risk from antimony trioxide was estimated to be 0.025 (25 in 1000) for persons working with flame retardants in plastics and textiles for 40 years. In addition, the available mechanistic and other relevant data (such as disposition and toxicokinetics) are assessed, and the final listing recommendation is based on an integration of all the relevant information (as summarized in the table above). Results In typical case scenarios, the occupational cancer risk from antimony trioxide was estimated to be 0.025 (25 in 1000) for persons working with flame retardants in … Human studies are inconclusive regarding antimony exposure and cancer, while animal studies have reported lung tumors in rats exposed to antimony trioxide via inhalation. However, there are companies in the United States that produce antimony … The International Agency for Research on Cancer has concluded antimony trioxide is "possibly carcinogenic to humans" (IARC, 1989). level of evidence from cancer studies of antimony(III) trioxide in humans and experimental animals. Breathing air contaminated with antimony can cause eye and lung irritation, heart and lung damage, stomach pains, diarrhea, vomiting, and stomach ulcers. Little antimony is currently mined in the United States. Antimony trioxide is on the Proposition 65 list because it can cause cancer. Antimony sesquioxide; Antimonous oxide; Antimony oxide, Oxo-oxostibanyloxystibane; Diantimony trioxide . The HEEP for Antimony Oxides (U.S. EPA, 1985) and HEA for Antimony and Compounds (U.S. EPA, 1987) acknowledged there was suggestive evidence Uses advised against Not for food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet Antimony Oxide (Antimony trioxide) Antimony Oxide (Antimony trioxide) More information about Antimony Trioxide. Immediate steps should be taken to limit its spread to the environment. The .gov means it's official. Arsenic trioxide may also be used for other purposes not listed in this medication guide. One compound — antimony trioxide — is even believed to be carcinogenic, and antimony poisoning has also been known to lead to Adams-Stokes syndrome. Typical and worst-case inhalation scenarios in multiple occupational settings were used in risk estimation. Antimony trioxide is a white crystalline solid. Arsenic trioxide is used to treat a cancer of the blood and bone marrow called acute promyelocytic (pro-MYE-loe-SIT-ik) leukemia, or APL. Antimony trioxide is a compound used in the production of certain flame retardants and other industrial processes. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry. Identification Product Name Antimony(III) oxide Cat No. Date of Listing: 10/01/1990. Take off all contaminated clothing. Oxide of trivalent (+3) antimony and most commercially significant form of antimony. potential concern for human health based on its classification by international organizations as a substance that was found to cause cancer in laboratory animals Antimony (Sb) is a silver-white brittle solid or a dark-gray, lustrous powder. Antimony trioxide is classified as a carcinogen in the state of California. Mouse intraperitoneal LD 50 =172 mg kg −1. Exposure to antimony trioxide may increase the risk of cancer. The Department of Health and Human Services (HHS) considers antimony trioxide to be reasonably anticipated to be a human carcinogen (causing cancer in people). SAFETY DATA SHEET Creation Date 22-Dec-2009 Revision Date 18-Jan-2018 Revision Number 5 1. For this reason, some items on this page will be unavailable. Workers may be harmed from exposure to antimony and its compounds. We will assist you in accessing the content of these files. Supplemental materials for events, meetings, and workshops prior to 2017 have been archived. Antimony trioxide was tested for carcinogenicity by inhalation exposure in male and female rats of one strain and in female rats of another strain, producing a significant increase in the incidence of lung tumours (scirrhous and squamous- cell carcinomas and bronchioloalveolar tumours) in … Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. 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